The Efficacy of Hyaluronic Acid Binding (HAB) in the Treatment of Male Infertility: A Systematic Review of the Literature

Hyaluronic acid (HA)-binding is reported to predict the fertilising capacity of spermatozoa, while HA-bound sperm selection reduce incidence miscarriage. However, clinical effectiveness these techniques remains uncertain. This work investigated prognostic value sperm-HA binding (HAB) as a predictor treatment outcomes, and whether HAB-sperm for Invitro fertilisation (IVF)/intracytoplasmic injection (ICSI) improves outcomes or reduces miscarriage rates. A systematic review literature was carried out. modified version Downs Black Checklist used assess bias study quality on eleven selected studies. No significant correlations were found between HAB score fertilisation, pregnancy, live birth rates (low-quality evidence). Three studies reduction in miscarriage, including Cochrane While scores currently undetermined, there evidence that prior insemination following ART. Moreover, are no reports detrimental effects when compared with conventional IVF ICSI. Therefore, it unclear why assigned “add-on” red light by HFEA, its routine use not recommended.